اليكس رمزي يحصل على شهاده الماجستير
حصل طالب الماجستير ALEX RAMZI على شهاده الماجستير عن اطروحته
(GAP JUNCTION EFFECTS IN THE CENTRAL NERVOUS SYSTEM)
-Role of Fast-Spiking interneurons in Striatum
من الجامعه الملكيه السويديه في ستوكهولم (KTH) وبدرجه امتياز
جرت المناقشه بوم الخميس 16-02-2006 ،و تالفت لجنه المناقشه من.
Professor Anders Lanner
Dr.Jeanette Helgr
Dr.Johannes Hjort
Researcher Ebba Samuelsson,Cecila Lundin
وسيتم نشر موضوع البحث في صفحه البحوث العالميه،و يرسل الى الموتمر الخامس عشر لدراسه البحوث العلميه الدي يعقد صيف 2006 في لندن
(Fifteenth Annual Computational Neuroscience Meeting CNS*2006)
وتم قبوله لتكمله دراسته للحصول على شهاده الدكتوراه فيNeuroscience Department
الف مبروك عزيزنا اليكس و لوالديك الاعزاء رمزي و عواطف على هذا التفوق العلمي مع التحيات بالموفقيه والنجاح الدائم لكل ابناء شعبنا.......[/b]
لكتابة التهاني للاخ اليكس انقر هنا: http://www.ankawa.com/forum/index.php/topic,29011.0.htmlملخص الاطروحة بالانكليزية
Master Thesis: Alex Ramzi
Abstract
To understand how the brain works, we need to combine experimental studies of animal and human nervous systems with numerical simulation of large-scale brain models.
This master thesis is based on novel hypotheses that electrical couplings (gap junctions) between Fast Spiking (FS) inhibitory interneurons are important and quite prevalent in the central nervous system (CNS). Specifically FS neurons in Striatum (the main input stage of the basal ganglia) are interconnected by gap junctions and this influences and controls the spike discharges of neurons in this area of the brain.
We have here investigated different aspects to lay a ground for how gap junctions' connectivity might influence spike patterns in FS cells. We have used a program package called GENESIS that allows the construction and simulations of realistic biological simulation in the nervous system. The all-embracing goal of this work is to describe the possible differences in the role played by gap junctions depending on how they are distributed in the dendritic tree. The consequences of transient inputs have been discussed too.
We were able to show that distal gap junctions are functionally weaker than proximal gap junctions, despite the same steady state coupling strength, when proximal inputs are given. With distal inputs, however, we could observe that distal inputs have stronger effect.
A follow up of this study, where, the consequences of gap junctions have been studied in FS networks with physiological synaptic inputs, has been submitted to the CNS06 (The Fifteenth Annual Computational Neuroscience Meeting) this summer in the UK.
الكاتب
